Biomedical researchers have a high and growing need for proteins
and cell lines. Many organizations lack the time or expertise to satisfy this need. As a contract manufacturer,
Impact Biologicals produces these reagents for its clients, thereby allowing clients to focus on
more critical activities. Impact Biologicals provides
an experienced and skilled outsourcing option for protein
and cell line work. This work can include development of new methods, or routine performance / scale-up of processes
that have already been developed by clients.
Impact Biologicals emphasizes the use of tried-and-true core technologies. It is our belief that a
few key technologies, carried out rigorously using standardized procedures, provide the best opportunity to quickly
produce successful results in most cases.
- Protein expression in E. coli, typically with pET vectors
- Transient transfection of mammalian cell lines to rapidly generate small amounts of processed protein for
- Generation of stable mammalian cell lines (CHO, HEK)
- Baculovirus expression in insect cells
- Protein purification, often using His6 or other tags
Company founder and president Bernard Selling, Ph.D., has over twenty years of experience in the pharmaceutical industry, including seven years managing core groups responsible for protein and cell line generation at large pharmaceutical companies. He and the groups he managed
have produced hundreds of proteins and cell lines for a variety of applications including antiserum production, high-throughput screening, lead optimization, and structure-based drug design employing x-ray crystallography and NMR.
Services related to proteins and cell lines
In addition to producing proteins and cell lines, Impact Biologicals carries out related
services such as design and construction of expression vectors, development of ELISAs and other
assays to measure protein amount or activity, development of cell-based assays, and more.
Inquiries are welcome.
Dr. Selling will visit your facility, review your procedures and results,
and offer suggestions.
715 Harvard Ave., Swarthmore, PA 19081